B. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

Chapter 2. Cell-Matrix Interactions. [that determine biomaterials function in vitro and in vivo] A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?

CELLS FOR TISSUE ENGINEERING/REGENERATIVE MEDICINE Autologous -Differentiated parenchymal cells of same or other tissue type -Stem cells (adult) Allogeneic

SACHUSE Massachusetts Institute of Technology Harvard Medical School Brigham and Women's/Massachusetts General Hosp

The Extracellular Matrices Part. 2. Elastin fibers. 3. Proteoglycans(PG) and glycosaminoglycans (GAG). 4. Cell-adhesion molecules (CAM)

biologically active model of ECM acts as an insoluble regulator of cell function image removed due to copyright considerations

2.4.1 Cell Activities \Packaged\ sequences (cascades) of cell activities/functions with an identifiable beginning and an end 2.4.1.1 Mitosis(Proliferation) Mitosis is a complex of processes leading to the division of a cell such that the two daughter nuclei receive identical complements of the number of chromosomes characteristic of the cells of the species. All cells arise from the division of pre-existing cells. The process of mitosis is divided into four phases:

Outline of three lectures on Irreversible Healing of Extracellular Matrix. A. Irreversible healing of ECMs in different organs. B. Structure and function of naturally occurring ECMs. C. Synthesis of biologically active ECM models

Introduction. Chapter 1. Irreversible Healing of Extracellular Matrix. Chapter 2. Cell-Matrix Interactions. Chapter 3. Synthesis of Tissues and Organs. TEXT: I. V. Yannas. Tissue and Organ Regeneration in Adults. New York: Springer, 2001

TISSUE Tissue is a biological structure made up of cells of the same type. - Cells of the same phenotype(e., same genes expressed). An aggregation of morphologically similar cells and associated extracellular matrix acting together to perform one or more specific functions in the body. - There are four basic types of tissue: muscle, nerve, epithelia, and connective. An organ is a structure made up of or more tissues