Wang Xiaochuan Children’s Hospital Immunocompromised Host Individual who has one or more defects in the body’s natural defense mechanisms which are sufficiently severe to predispose the host to life￾threatening infection Primary - PID, damage to anatomical barriers Secondary - infection, tumor, drug, others Physiology- Infants, aged

Vitamin D roles Facilitate intestinal absorption of calcium and phosphorus Promote renal reabsorption of phosphorus Direct effect on bone deposition and reabsorption of calcium and phosphorus Maintain calcium and phosphorus homeostasis

Definition PEM is a kind of malnutrition caused by inadequate dietary intake or some diseases, occurs commonly in children under 3 years of age

Overview 1. Definition of Accidental Trauma： Accident, Unexpected, Injuries Physically and/or Psychologically 1. Causes: physical, chemical, and biological factors 2. Main cause of mutilation and death in children globally

1. 意外伤害(Unintentional Injury) ：突然发生的事件对人体所造成的肉体和精神上的伤害，原因包括物理、化学和生物等各种因素，是儿童致伤、致残、致死的主要原因之一

Bacteremia： Bacteria invade into blood temporarily with flora <100 CFU/ml in blood Septicemia or Sepsis： Pathogens(bacteria or fungi) invade into blood,proliferate greatly,and release endotoxin Toxemia： Endotoxin absorbed into blood with no bacteria Septicopyemia：

Bacteremia： Bacteria invade into blood temporarily with flora <100 CFU/ml in blood Septicemia or Sepsis： Pathogens(bacteria or fungi) invade into blood,proliferate greatly,and release endotoxin Toxemia： Endotoxin absorbed into blood with no bacteria Septicopyemia：

一、Definition 二、 Etiology 三、Pathology 四、Pathophysiology 五、Clinical Manifestation 六、Laboratory Data 七、Diagnosis 八、Therapy and Prognosis

一、基本概念 二、病因 三、病理生理 四、病理 五、临床表现及分类:分类、度、型 六、诊断 七、治疗

Professor and Chairman Department of Pediatrics, Tongji Hospital Director, Center for the Diagnosis of Genetic Metabolic Diseases Tongji Medical College Huazhong University of Science and Technology Adjunct Professor