Medical Genetics Mutations (changes) in the mitochondrial chromosome are responsible for a number of disorders

◼ Introduction of the basic concepts 2. What Causes Cancer? ◼ Genetic underpinnings of cancer ◼ Three types of Cancer Critical Genes ◼ Cancer initiation and progression 3. How to Prevent and Diagnose Cancer? ◼ Utilization the knowledge we learned from cancer genetics Outline

A. Historical background B. Phenotypes in populations C.Genes in populations D.Mapping disease genes E. Complex disorders

1.Genes can be mutated in many ways 2. Somatic versus germline mutations 3. Types of mutation effects

1. Variability and Gene (or Allelic) Frequencies 2. The Hardy-Weinberg Law 3. Factors that Affect Stability of Gene Frequencies

2. Inborn Errors of Metabolism Inborn errors of metabolism are rare genetic disorders in which the body cannot turn food into energy (metabolize food) normally. The disorders are usually caused by defects in the enzymes involved in the biochemical pathways that break down food components

1. General 2. Etiology 3. Symptoms and Signs 4. Diagnosis

1. What is gene therapy? 2. How does gene therapy work? 3. The current status of gene therapy research 4. Factors kept gene therapy effective 5. Some recent developments 6. Some of the ethical considerations

复旦大学：《医学遗传学 Medical Genetics》课程教学资源（习题与解答）2010-2011（1）answer

复旦大学：《医学遗传学 Medical Genetics》课程教学资源（习题与解答）2012-2013（1）-A answer