Neurodegenerative diseases and ubiquitin-proteasome syster to copyright considerations See Figure chanover, A and Brundin, P. 2003. The ubiquitin proteasome enerative diseases: sometimes the chicken, sometimes the egg

The Cell and Its Membrane Molecules Plasma membrane-5nm Rough ER Smooth ER Nucleus-3-10 um Nucleolus Nuclear pore -Golgi complex Extracellular

BIOMATERIALS-TISSUE INTERACTIONS: \Tools\ for Understanding the Molecular, Cellular, and Physiological, Bases of the Tissue Response to Implants M. Spector, Ph. D. and I. V. Yannas, Ph.D. BIOMATERIALS-TISSUE INTERACTIONS

UNIT CELL PROCESSES Regulator UCP Cell Matrix Product Regulator Connect. ECM Mitosis Tiss. Adhesion Sy Synthesis Epithelia |Protein Migration Muscle Collagen

RESPONSE TO IMPLANTS WOUND HEALING flury Vascular Response Inflammation Tissue of labile Tissue of and stable cells Permanent cells Framework framework Scar Intact Destroyed

RESPONSE TO IMPLANTS: WOUND HEALING Surgical Implantation Inc. time Vascular Response Acute Clotting Inflammation Phagocytosis Granulation Neovascularization New Collagen Synthesis Tissue

The Extracellular Matrices Part. 2. Elastin fibers. 3. Proteoglycans(PG) and glycosaminoglycans (GAG). 4. Cell-adhesion molecules (CAM)

TISSUE ENGINEERING What is tissue engineering Production of tissue in vitro by growing cells in porous, absorbable scaffolds (matrices). Why is tissue engineering necessary? Most tissues cannot regenerate when injured or diseased

UNIT CELL PROCESSES Concept of a \Control Volume\ around a Cell Soluble Regulator Cell Matrix

C. Cell-Matrix Interactions A. How cells pull onto and deform the matrix to which they attach themselves. B. Cell-matrix interactions control the spontaneous closure of wounds in organs. C. What happens when regeneration is induced?