Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Solid Polymeric Materials(continued) hemistry and physical chemistry of degrading polymeric solids for biomaterials Today Theory of polymer erosion Enzymatic degradation of synthetic biomaterials Designing degradable materials Reading
Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release
Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost
Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester
Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law
Lecture 8: Physical Hydrogels Last Day Overview of biomedical applications of hydrogels Structure of covalent hydrogels Thermodynamics of hydrogel swelling Today Bonding in physical hydrogels Structure and thermodynamics of block copolymer hydrog Reading
Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting
Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading
