Unit #10- Principle of minimum potential energy and Castigliano's First Theorem Principle of minimum potential energy The principle of virtual displacements applies regardless of the constitutive law. Restrict attention to elastic materials(possibly nonlinear). Start from the Pvd

Brannon-Peppas theory of swelling in ionic hydrogels Original theory for elastic networks developed by Flory and Mehrer, refined for treatment of ionic hydrogels by Brannon-Peppas and Peppas Other theoretical treatments Derivation of ionic hydrogel swelling Model structure of the system

Molecular switches in the cell: fibronectin as a mechanical switch (vogel, 2002) Fibronectin is an adhesion protein secreted by cells and assembled into fibrils to support adhesion and migration Composed of\ of fibronectin repeats Fnl, Fnll, and Fnlll connected by short linkers of varying flexibility One particular Fnlll repeat, Fnlll10

molecular switches Proteins as motors in nanodevices Today. nano-and micro-particle drug carriers Reading D A Hammer and D.E. Discher, ' Synthetic cells- Self-assembling polymer membranes and bioadhesive colloids, Annu. Rev. Mater Res, 31, 387-404 (2001) Nano- and Micro-scale Drug Carriers and Detection Reagents Nano- to Micro-particle polymer-protein

Lecture 16: Intracellular drug delivery Last time nano- and micro-particle drug carriers Delivery to tissues from systemic circulation Today. Intracellular drug delivery Reading A.S. Hoffman et aL., Design of \smart polymers that can direct intracellular drug delivery, Polym. Adv. Technol. 13, 992-999(2002) Ph gradients and drug delivery: cancer res. 56, 1194(1996): adv drug deliv rev 25, 3 (1997); see asokan minireview

A recent study of controlled release of a model small-molecule drug from poly (lactide-co-glycolide) microspheres prepared by the single-emulsion method found that the diffusion constant of the drug through the polymer was best related to the polymer's molecular weight according to

5 points/problem(20 points total) 1. Two hydrogels are prepared from two different candidate polymers for controlled release of a protein drug, interleukin-2(IL-2). The gels exhibit the same swelling ratio at equilibrium, but jel a (formed by cross-linked polymer A, repeat unit molecular weight Mo= 100 g/mole)has a molecular weight between cross-links of 3,000 g/mole, while gel B (formed from cross linked polymer B, Mo=95 g/mole) has a molecular weight between crosslinks of

A recent study of controlled release of a model small-molecule drug from poly(lactide-co-glycolide) microspheres prepared by the single-emulsion method found that the diffusion constant of the drug through the polymer was best related to the polymers molecular weight according

Please print out this problem set and record your answers on the printed copy. Answers to this problem set are to be turned in at the box by 4: 10 Wednesday, September10. Problem sets will not be accepted late. Solutions will be posted on the web

Many intracellular proteins are required to interact or bind to other macromolecules within a bind DNA. Such proteins often have conserved structural features, called motifs, whis at can cell in order to function properly. One class of such proteins is comprised of proteins tha interact with DNA. One such motif consists of two closely aligned a-helices(shown as cylinders below)that each have leucine-rich regions. This motif is referred to as a leucine