Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law

Lecture 9: Polyelectrolyte Hydrogels Last Day: Physical hydrogels Structure and chemistry Toda polyelectrolyte hydrogels, complexes, and coacervates rolyte multilayer theory of swelling in ionic hydrogels Reading S.K. De et aL., 'Equilibrium swelling and kinetics of pH-responsive hydrogels: Models experiments, and simulations

Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering

Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost

Lecture 3: Degradable Materials with Biological Recognition Last time: Theory of hydrolytic polymer erosion Enzymatic degradation of polymers Designing Biodegradable Macromolecules Today: Biological recognition in vivo Engineering biological recognition of biomaterials: cell adhesion/migration Reading: S.E. Sakiyama-Elbert and J.A. Hubbell, 'Functional Biomaterials: Design of Novel

Biological recognition in vivo Engineering biological recognition of biomaterials: adhesion/migration peptides Engineering biological recognition of biomaterials: enzymatic recognition and cytokine Reading S.E. Sakiyama-Elbert and J.A. Hubbell, Functional Biomaterials: Design of Novel

1900年孟德尔遗传规律重新发现以后,生物界广泛重 视,进行了大量试验。 其中有些属于两对性状的遗传结果不符合独立分配规律 ,因此不少学者对于孟德尔的遗传规律曾一度发生怀疑。 摩尔根以果蝇为试验材料进行深入细致的研究→ 提出连锁遗传规律(遗传学第三规律)→创立基因论 →认为基因成直线排列在染色体上,进一步发展为细 胞遗传学

最轻的固体:气凝胶 美国国家宇航局研制出的一种新型气凝胶,由于密度只有每立方厘米3毫克,日前 已经作为“世界上密度最低的固体”正式入选《吉尼斯世界纪录》。 这种气凝胶呈半透明淡蓝色,重量极轻,因此人们也把它称为“固态烟”。 新型气凝胶是由美国国家宇航局下属的“喷气推进实验室”材料科学家史蒂芬·琼 斯博士研制的。它的主要成分和玻璃一样也是二氧化硅,但因为它998%都是空气,所 以密度只有玻璃的千分之 别看这种气凝胶貌似“弱不禁风”其实非常坚固耐用

第一节施工组织设计 第二节施工项目管理概述 第三节施工项目进度管理 第四节施工项目劳动管理 第五节施工项目材料管理 第六节施工项目现场管理