Lecture 5: Controlled Release Devices Last time: Using enzyme substrate and cytokine peptides to engineer biological recognition of synthetic polymers Today: principles of controlled release devices based on degradable polymers Synthesis of controlled release devices Theory of polymer-based controlled release

Example: HIV-1 DNA vaccine delivered with boosters to elevate Ab titers2: Mechanical and electrical devices that can provide digitized release typically require larger devices and surgical implantation(e.g. Pharm. Res. 1, 237(1984); also have high cost

Molecular Principles of Biomaterials Spring 2003 Lecture 2: Molecular Design and Synthesis of Biomaterials I: Biodegradable Materials Chemistry of Biodegradable Materials Hydrolytically degraded biomaterials Common hydrolytically unstable linkages Ester

Lecture 10: Bioengineering applications of hydrogels: Molecular Imprinting and Drug Delivery Last Day polyelectrolyte gels Polyelectrolyte complexes and multilayers Applications in bioengineering Theory of ionic gel swelling Toda Molecular imprinting

detection methods Surface plasmon resonance biosensors Today cell- and tissue-based sensors Primary transducers and biosensor design with living cells microphysiometer Reading J.J. Pancrazio et al., Development and application of cell-based biosensors, Ann Biomed

engineering intracellular delivery Drug targeting Today biosensor device classes Detection methods Overview of biosensor technology Classes of biosensor devices External analysis/detection

Lecture 17: Drug targeting Last time Intracellular drug de Today Drug targeting Reading T.J. Wickham, 'Ligand-directed targeting of genes to the site of disease, Nat. Med. 9(1) 135-139(2003)

Lecture 13: Molecular Devices Last time biological strategies for inorganic templating by organic materials Biomimetic organic template materials Biomimesis of bone Today Reading V Vogel, 'Reverse engineering: Learning from proteins how to enhance the performance

Lecture 12: Organic templating of inorganic materials and bone biomimesis Last time interfacial biomineralization and biomimetic inorganic chemistry Today biological strategies for inorganic templating by organic materials Biomimetic

Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law