insolubility. Administration of cystamine, a transglutaminase inhibitor, reduces the To date, 10 neurological diseases, including aggregate formation, retarding the Huntington's and several ataxias, are caused development of neurological phenotype and by the lengthening of glutamine(@) tracts in prolonging the life span of brain cells in various proteins with no obvious functional or transgenic mouse models

Epstein-Barr virus (EBV), is the herpesvirus that causes infectious mononucleosis and is associated with a number of cancers, particularly lymphomas in immunosuppressed persons including persons with AIDS EBV is a ubiquitous virus, so common that it has been difficult to determine whether it is the cause of certain diseases or whether it is simply there as an artifact

Images removed due to copyright considerations See Fig. 2 in David J. Katzmann, Greg Odorizzi Scott D. Emr RECEPTOR DOWNREGULATION AND MULTIVESICULAR-BODY SORTING Nature Reviews Molecular Cell Biology 3, 893-905(2002); doi: 10.1038/nrm973 See Fig. 7 in: Katzmann DJ, Stefan CJ, Babst M, Emr SD

Lecture D32: Damped Free Vibration Spring-Dashpot-Mass System k Spring Force Fs =-kx, k>0 Dashpot Fd =-cx, c>0 Newton's Second Law (mx =EF) mx +cx+kx (Define)Natural Frequency wn=k/m,and

When the only force acting on a particle is always directed to- wards a fixed point, the motion is called central force motion. This type of motion is particularly relevant when studying the orbital movement of planets and satellites. The laws which gov- ern this motion were first postulated by Kepler and deduced from observation. In this lecture, we will see that these laws are a con- sequence of Newton's second law. An understanding of central

In this lecture, we will derive expressions for the angular momentum and kinetic energy of a 3D rigid body. We shall see that this introduces the concept of the Inertia Tensor. Angular Momentum We start form the expression of the angular momentum of a system of particles about the center of mass

In this lecture, we will particularize the conservation principles presented in the previous lecture to the case in which the system of particles considered is a 2D rigid body. Mass Moment of Inertia In the previous lecture, we established that the angular momentum of a system of particles relative to the center of mass, G, was

In this lecture, we will start from the general relative motion concepts introduced in lectures D11 and D12. and then apply them to describe the motion of 2D rigid bodies. We will think of a rigid body as a system of particles in which the distance between any two particles stays constant. The term 2-dimensional implies that particles move in parallel planes. This includes, for instance, a planar body moving within its plane

In the previous lecture, we related the motion experienced by two observers in relative translational motion with respect to each other. In this lecture we will extend this relation to our third type of observer.That is, observers who accelerate and rotate with respect to each other. As a matter of illustration, let us consider a very simple situation, in which a particle at rest with respect

In this lecture we will consider the equations that result from integrating Newtons second law, F=ma, in time. This will lead to the principle of linear impulse and momentum. This principle is very useful when solving problems in which we are interested in determining the global effect of a force acting on a particle over a time interval Linear momentum We consider the curvilinear motion of a particle of mass, m, under the influence of a force F. Assuming that