1、掌握机械性损伤的概念及机械性损伤三要素; 2、了解机械性损伤的成伤原理及损伤分类; 3、着重掌握机械性损伤的基本形态学特征; 4、着重掌握机械性损伤的法医学鉴定要点

1、掌握机械性窒息的形态学变化; 2、掌握缢死、勒死、扼死、溺死的形态学变化特征和法医学鉴定要点; 3、掌握溺死的相关实验室检查方法、评价; 4、熟悉挤压性窒息、体位性窒息的形态特征及法医学鉴定;

1、重点: （1)颅脑损伤; （2)颈部损伤。 2、难点: （1)颅脑损伤的类型及形成机理; （2)颈部损伤的类型及形成机理

1、在充分复习颅脑解剖生理结构基础上,了解颅脑损伤的特点及分类 2、掌握头皮损伤及颅骨骨折的类型,形态学特征及法医学意义。 3、掌握硬脑膜外出血与硬脑膜下出血的分期、形态学特征及法医学意义

1、掌握现场尸体外表检验方法; 2、掌握法医解剖程序、方法; 3、掌握脏器检验方法及检材的采取方法; 4、熟悉特殊尸体检查方法; 5、了解组织切片染色方法及程序

FATTY CHANGE Excessive entry of free fatty acids into the liver (starvation, corticosteroid therapy). Enhanced fatty acid synthesis. Decreased fatty acid oxidation. Increased esterification of fatty acid to triglycerides (alcohol). Decreased apoprotein synthesis (CCl). Impaired lipoprotein secretion from the liver (alcohol)

Definition of pathology Pathology is to study diseases by scientific methods. Disease may be defined as an abnormal alteration of structure or function in any part of the body

CELLULAR ADAPTATION Excessive physiologic stresses. Some pathologic stimuli. A new, but altered state preserving the viability of the cell

Motional pathway of embolus: Embolus from left heart cavity or arterial system Embolus from right heart cavity or venous system Embolus from portal veins Paradoxical embolism Retrograde ethrombus

ANTITHROMBOTIC PROPERTIES Inhibition of platelet aggregation: PGL NO, ADPase Anticoagulant -binding and inhibition of thrombin: Antithrombin acceleration by heparin-like molecules, thrombomodulin activation of protein C/S, a2-macroglobulin. Fibrinlysis: Tissue plasminogen activator (tPA)