Please print out this problem set and record your answers on the printed copy. Answers to this problem set are to be turned in at the box outside by 4: 10 Wednesday, October I Problem sets will not be accepted late Solutions will be posted on the web October 2

Please print out this problem set and record your answers on the printed copy. Answers to this problem set are to be turned in at the box outside by 4: 10 Wednesday, September 17. Problem sets will not be accepted late. Solutions will be posted on the web

1. Two hydrogels are prepared from two different candidate polymers for controlled release of a protein drug, interleukin-2(IL-2). The gels exhibit the same swelling ratio at equilibrium, but gel A(formed by cross-linked polymer A, repeat unit molecular weight Mo= 100 g/mole)has

1. (4 pts) An early study in the development of peptide-presenting biomaterials showed that polymer surfaces bearing RGD peptides at a density equivalent to -10 peptides per each cell was sufficient to promote cell attachment, spreading and subsequent cell growth. In contrast, when whole fibronectin protein was adsorbed to polymer surfaces, it was found that many more copies of the

Lecture 19: Biosensors(continued ast time: biosensor device cla Gene array biosensor Today detection methods Detection Elements Macroscopic fluorescence, diffraction, or interference ·what Example: quantum dot-loaded microsphere capture agents QDs show size-dependent luminescence Narrow emission bands from a common excitation wavelength

Lecture 15: Stealth' particles Last time Nano- and micro-particle carriers Today Delivery of drugs to tissue from circulation stealth particles theory and function Reading S. Stolnik et al. 'Long circulating microparticulate drug carriers, Adv. Drug. Deliv. Rev 16,195(1995) Delivery of drugs to tissues via systemic circulation

Lecture 11: Molecular Design and Synthesis of Biomaterials Il: Inorganic Biomaterials Last time: hydrogel applications: molecular imprinting and responsive drug delivery Today biomineralization and biomimetic inorganic/organic composites Inorganic biomaterials Reading L A. Estroff and A D. Hamilton, ' At the interface of organic and inorganic chemistry

Lecture 9: Polyelectrolyte Hydrogels Last Day: Physical hydrogels Structure and chemistry Toda polyelectrolyte hydrogels, complexes, and coacervates rolyte multilayer theory of swelling in ionic hydrogels Reading S.K. De et aL., 'Equilibrium swelling and kinetics of pH-responsive hydrogels: Models experiments, and simulations

Strain energy and potential energy of a beam brec sedans hoMe the neutra xxis remain So Figure 1: Kinematic assumptions for a beam Kinematic assumptions for a beam: From the figure: AA'=u3(a1) Assume small deflections: B B\,BB\=3+ duy

Lecture 3: Degradable Materials with Biological Recognition Last time: Theory of hydrolytic polymer erosion Enzymatic degradation of polymers Designing Biodegradable Macromolecules Today: Biological recognition in vivo Engineering biological recognition of biomaterials: cell adhesion/migration Reading: S.E. Sakiyama-Elbert and J.A. Hubbell, 'Functional Biomaterials: Design of Novel