1. Two hydrogels are prepared from two different candidate polymers for controlled release of a protein drug, interleukin-2(IL-2). The gels exhibit the same swelling ratio at equilibrium, but gel A(formed by cross-linked polymer A, repeat unit molecular weight Mo= 100 g/mole)has

Lecture 19: Biosensors(continued ast time: biosensor device cla Gene array biosensor Today detection methods Detection Elements Macroscopic fluorescence, diffraction, or interference ·what Example: quantum dot-loaded microsphere capture agents QDs show size-dependent luminescence Narrow emission bands from a common excitation wavelength

5 points/problem(20 points total) 1. Two hydrogels are prepared from two different candidate polymers for controlled release of a protein drug, interleukin-2(IL-2). The gels exhibit the same swelling ratio at equilibrium, but jel a (formed by cross-linked polymer A, repeat unit molecular weight Mo= 100 g/mole)has a molecular weight between cross-links of 3,000 g/mole, while gel B (formed from cross linked polymer B, Mo=95 g/mole) has a molecular weight between crosslinks of

从材料的晶体结构出发,研究了双相不锈钢超塑性变形的机理.利用背散射电子衍射花样分析系统(EBSD),获得了双相不锈钢变形过程中的ODF图、极图和取向与转轴分布等晶体取向分布规律.结合透射电镜对微观组织的观察结果进行了综合分析.研究表明,双相不锈钢超塑性变形的机理为形变诱导析出和动态再结晶、晶界滑移以及变形中的晶粒转动

A recent study of controlled release of a model small-molecule drug from poly (lactide-co-glycolide) microspheres prepared by the single-emulsion method found that the diffusion constant of the drug through the polymer was best related to the polymer's molecular weight according to

Lecture 15: Stealth' particles Last time Nano- and micro-particle carriers Today Delivery of drugs to tissue from circulation stealth particles theory and function Reading S. Stolnik et al. 'Long circulating microparticulate drug carriers, Adv. Drug. Deliv. Rev 16,195(1995) Delivery of drugs to tissues via systemic circulation

1. (4 pts) An early study in the development of peptide-presenting biomaterials showed that polymer surfaces bearing RGD peptides at a density equivalent to -10 peptides per each cell was sufficient to promote cell attachment, spreading and subsequent cell growth. In contrast, when whole fibronectin protein was adsorbed to polymer surfaces, it was found that many more copies of the

蜗杆传动概述 失效形式与设计准则 材料选择与结构形式 主要参数和几何关系 蜗杆传动受力分析 蜗杆传动的强度计算 蜗杆传动的挠度计算 蜗杆传动的润滑、温度计算

Lecture 16: Intracellular drug delivery Last time nano- and micro-particle drug carriers Delivery to tissues from systemic circulation Today. Intracellular drug delivery Reading A.S. Hoffman et aL., Design of \smart polymers that can direct intracellular drug delivery, Polym. Adv. Technol. 13, 992-999(2002) Ph gradients and drug delivery: cancer res. 56, 1194(1996): adv drug deliv rev 25, 3 (1997); see asokan minireview

Brannon-Peppas theory of swelling in ionic hydrogels Original theory for elastic networks developed by Flory and Mehrer, refined for treatment of ionic hydrogels by Brannon-Peppas and Peppas Other theoretical treatments Derivation of ionic hydrogel swelling Model structure of the system