Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells.（造血干细胞） Leukemia is a malignant blood disorder. (not solid tumor)

1.Definition It is directly caused by chronic alterations in pulmonary circulation or chronic chest diseases that lead to pulmonary arterial hypertension, right ventricular enlargement, even right heart failure

Various causes Graves disease: 85% Autonomous toxic adenomas of the thyroid: Plummer's disease or toxic multinodular

RF negtive low back pain and stiffness other joints enthesitis familial aggregation

Factors cause diseases： chemicals physical biological psychological chemicals：occupational, non-occupational. physical：occupational, non-occupational

Definition：A group of neoplastic diseases of lymphoid tissues Classification： Hodgkin′s Disease, HD (Hodgkin′s Lymphoma) Non Hodgkin ′s Lymphoma,NHL) General considerations

Bone marrow hematopoiesis failure led by chemicals, radiation, biological factors and unknown etiology. The common clinical presentation is mild to severe pancytopenia

Definition Absent iron-store hemoglobin synthesis↓ A microcytic and hypochromic anemia The most common nutritional anemia

Anemia of increased destruction Normochromic, normochromic anemia Shortened RBC survival Reticulocytosis--Response to increased RBC destruction Increased indirect bilirubin Increased LDH

Chronic Renal Insufficiency Pathogen and pathogenesis Manifestation Laboratory examination Diagnosis and differential diagnosis Treatment