the B-cell rec and diffict Interaction of aB TCR with Class II MHC-Peptide Early Studies of the T-Cell Receptor complex cel aB and yo T-Cell Receptors: Structure and Roles ficity. Sec Organization and Rearrangement of TCR Genes gen alone by the major histo T-Cell Receptor Complex: TCR-CD3 erty precludes pur
possesses a tightly linked cluster of genes. the ma jor products play roles in intercellular recognition and in dis on of vesicular Stomatitis Virus Peptide (top) Class I Molecule H-2K General Organization and Inheritance of the MHC MHC Molecules and Genes that Detailed Genomic Map of MHC Genes Cellular Distribution of MHC Molecules antigens of Regulation of MHC Expression implicated MHC and Immune Responsiveness natural killer
Kappa Light-Chain Gene Rearrangement the vertebrate immune system is its ability to respond to an apparently limitless array of for eign antigens As immunoglobulin(Ig)sequence data accu- a Genetic Model Compatible with Ig Structure mulated, virtually every antibody molecule studied was found to contain a unique amino acid sequence in its vari a Multigene Organization
cell receptor when complexed with MHC,are called antigens. The molecular properties of antigens and he way in which these properties ultimately contribute to immune activation are central to our understanding of the mmune system. This chapter describes some of the molecu- Complementarity of Interacting Surfaces of Antibody(left) lar features of antigens recognized by B or T cells. The chap and Antigen(rig ter also explores the contribution made to immunogenicity by the biological system of the host; ultimately the biological system determines whether a molecule that combines with a a Immunogenicity Versus Antigenicity Bor T cells antigen-binding receptor can then induce an im
defense system that has evolved to protect animals from invading pathogenic microorganisms and ancer. It is able to generate an enormous variety of cells and molecules capable of specifically recognizing and eliminat ing an apparently limitless variety of foreign invaders. These cells and molecules act together in a dynamic network whose omplexity rivals that of the nervous system. Functionally, an immune response can be divided into two related activities--recognition and response. Immune
Structural proteomics Structural proteomics has the goal o obtaining useful, three-dimensional models of all proteins by a combina- tion of experimental structure determination and comparative model building 10/272005 Chaoqun Wu, Fudan University
