概念:体积微小、结构简单、只含有一种类型的核酸,必须在易感的活 细胞内以复制的方式进行增殖的非细胞型微生物成熟的病毒体称为病毒体

第一节 MHC结构及其多基因特性 第二节 MHC的多态性（polymorphism） 第三节 MHC分子和抗原肽的相互作用 第四节 HLA与临床医学

一、教学目的（掌握、熟悉、了解的具体内容） 1. 掌握 SLE 累及多系统多脏器损害的临床表现、实验室检查及血清免疫学检测临床意义。 2. 熟悉 SLE 的诊断依据、治疗原则。 3. 了解 SLE 疾病的特点、诱发因素及病理学特征

一、教学目的 1. 掌握系统性血管炎（巨细胞动脉炎、大动脉炎 、结节性多动脉炎、显微镜下多血管炎、韦格氏肉芽肿、变异性肉芽肿性血管炎、白赫切特病）的临床表现、实验室检查及血清免疫学检测临床意义

production of plasma cells and memory B cells can be divided into three broad stages: generation of mature, immunocompetent B cells(maturation), activa- Initial Contact between b and T cells tion of mature B cells when they interact with antigen, and differentiation of activated B cells into plasma cells and memory B cells. In many vertebrates, ng humans B-Cell maturation and mice, the bone marrow generates B cells. This process

第一节 BCR、TCR基因结构和发生重排的一般特点 第二节 多样性产生的机制 第三节 BCR 基因表达的一些特点

一、肠杆菌科 共同特性: 1.形态结构:革兰阴性杆菌,多数有周鞭毛和菌 毛。 2.培养特性与生化反应: (1)对营养要求不高 (2)需氧或兼性厌氧 (3)生化反应活泼 3.抗原构造复杂

recognition by most T cells from recognition by B iction. In most cases, both th maturati vation of ma the involver diversity o CD4\ and CD class I MHC Activat Engagement of TcR by Peptide: MHC Initiates interaction of th n antigenic Signal Transduction tide displayed though the sp

the B-cell rec and diffict Interaction of aB TCR with Class II MHC-Peptide Early Studies of the T-Cell Receptor complex cel aB and yo T-Cell Receptors: Structure and Roles ficity. Sec Organization and Rearrangement of TCR Genes gen alone by the major histo T-Cell Receptor Complex: TCR-CD3 erty precludes pur

possesses a tightly linked cluster of genes. the ma jor products play roles in intercellular recognition and in dis on of vesicular Stomatitis Virus Peptide (top) Class I Molecule H-2K General Organization and Inheritance of the MHC MHC Molecules and Genes that Detailed Genomic Map of MHC Genes Cellular Distribution of MHC Molecules antigens of Regulation of MHC Expression implicated MHC and Immune Responsiveness natural killer