NMR spectroscopy in structure-based drug design Gordon CK Roberts NMR methods for the study of motion in proteins continue Structure and dynamics of the binding site improve, and a n d complexes Methodological developments in NMR of macromolecules relevant to drug design
SPE'TROSCO)Y LSI in Nuclear Magnetic Resonance Spectroscopy 32(1998)193-275 Technical aspects of nmr spectroscopy with biological macromolecules and studies of hydration in solution erhard Wider Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule, Honggerberg, CH-8093 Zurich, Switzerland
3. 1 Chemical shift When an atom is placed in a magnetic field B its electrons circulate about the direction of the applied magnetic field. This circulation causes a small magnetic field at the nucleus which opposes the externally applied field The magnetic field at the nucleus(the effective field) is therefore generally less than the applied field by a fraction THNMR