REGULAR PATTERN OF GROWTH AND DEVELOPMENT continuous process Different rate of development in various systems General pattern Individual variance Puberty13yr(F)/15yr(M)

Inborn errors of metabolism Overview Disorders in which defects of single gene cause clinically significant blocks in metabolic pathways Many kinds of disorders Lower incidence Clinical manifestations vary widely: mental retardation, seizure, hypotonia, failure to thrive

Main Points Historical changes in the definition or name of the disease Different views and definitions at home and abroad What is basis for the category

Background and Introduction Billirubin Metabolism Special problems in neonates Dangerous of the Hyperbillirubinemia The diseases in relation with Neonatal Jaundice

Introduction he or hibd? The relation with asphyxia How and when it happens Clinical diagnosis Advances in treating

Nutrition Basal matabolism Maintain basic physiologic activity Energy Special motility for food digestion peristalsis infant 7%-8% digestion absorption elder children 5%

病例1 10岁6个月的女孩,从小生长 慢,目前是同班同学中最矮的

一、如何进行心肺复苏? 二、如何利用现有条件进行复苏? 三、复苏初步成功以后怎么办?

案例一 男孩,6月20天,偏瘦,到儿保门诊 要求作全面体格检查,看其生长发育是 否正常? 需要作哪些客观指标检查?

一、掌握室间隔缺损、动脉导管未闭、房间隔缺损和法洛四联征等常见先心病的的诊断和鉴别诊断。 二、熟悉上述常见先心病的治疗原则和方法。 三、了解先心病诊断和治疗进展