PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY ELSEVIER Progress in Nuclear Magnetic Resonance Spectroscopy 38 (2001) 325-360 www.elsevier.nl/locate/pnmrs NMR quantum computation J.A. Jonesa,b,* \Oxford Centre for Molecular Sciences. New Chemistry Laboratory South Parks Road, Oxford OXI 3QT. UK

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY ELSEVIER Progress in Nuclear Magnetic Resonance Spectroscopy 38(2001)83-114 www.elsevier.nl/locate/pnmrs NMR studies of protein -DNA interactions N. Jamin“,F.Ton

NMR screening in drug discovery Jonathan M Moore NMR methods in drug discovery have traditionally been used drugs. Many pharmaceutical industry research groups have to obtain structural information for drug targets or embarked on drug discovery programs using NMR screen-

SPE'TROSCO)Y LSI in Nuclear Magnetic Resonance Spectroscopy 32(1998)193-275 Technical aspects of nmr spectroscopy with biological macromolecules and studies of hydration in solution erhard Wider Institut fur Molekularbiologie und Biophysik, Eidgenossische Technische Hochschule, Honggerberg, CH-8093 Zurich, Switzerland

nature publishing group http://structbio.nature.com news and views Department of Biological Sciences. chem.276146-116200 Columbia University, New York, New York 6. Chen,.. Sharma, 5. Quiocho, F.A. Davidson. A.L. 15. Jones. P.M. George. A.M. FEMS Microbiol. Lett

THE MATHEMATICS OF NMR EX ons Trigonometric Functions Differentials and Integral Coordinate Transformations Convolutions Imaginary Numbers The Fourier transform tial Functions

What is nmr? g NMR, Nuclear Magnetic Resonance, is a phenomenon which occurs when the nuclei of certain atoms are immersed in a static magnetic field and exposed to a second oscillating magnetic field

4.1 NMR HARDWARE Hardware overview Magnet Field lock Shim Coils Sample probe RF CoIls Gradient coils Qadrature Detector Digital Filtering

Welcome to the exiting world of NMR... though a little hard to learn... remember... .Why just NMR... .How a ID NMR spectrum look like... .What we can obtain from it... and what can we do for a big molecule

在样品管中溶液的深度由两个因子决定, 样品若超过一定高度,超过部分将会接收不到发射线圈发射的射频造成浪费; 若太低则样品与空气磁化率的不同造成界面磁化率突变会影响样品中磁场的均 匀性