detection methods Surface plasmon resonance biosensors Today cell- and tissue-based sensors Primary transducers and biosensor design with living cells microphysiometer Reading J.J. Pancrazio et al., Development and application of cell-based biosensors, Ann Biomed

Lecture 17: Drug targeting Last time Intracellular drug de Today Drug targeting Reading T.J. Wickham, 'Ligand-directed targeting of genes to the site of disease, Nat. Med. 9(1) 135-139(2003)

Lecture 15: Stealth' particles Last time Nano- and micro-particle carriers Today Delivery of drugs to tissue from circulation stealth particles theory and function Reading S. Stolnik et al. 'Long circulating microparticulate drug carriers, Adv. Drug. Deliv. Rev 16,195(1995) Delivery of drugs to tissues via systemic circulation

Lecture 13: Molecular Devices Last time biological strategies for inorganic templating by organic materials Biomimetic organic template materials Biomimesis of bone Today Reading V Vogel, 'Reverse engineering: Learning from proteins how to enhance the performance

Lecture 11: Molecular Design and Synthesis of Biomaterials Il: Inorganic Biomaterials Last time: hydrogel applications: molecular imprinting and responsive drug delivery Today biomineralization and biomimetic inorganic/organic composites Inorganic biomaterials Reading L A. Estroff and A D. Hamilton, ' At the interface of organic and inorganic chemistry

Lecture 12: Organic templating of inorganic materials and bone biomimesis Last time interfacial biomineralization and biomimetic inorganic chemistry Today biological strategies for inorganic templating by organic materials Biomimetic

Hydrogels in drug delivery Control of drug release kinetics by hydrogel structure6, Release from stable hydrogels is controlled by diffusion of solute through the network Diffusion is described by Fick,s second law

Lecture 9: Polyelectrolyte Hydrogels Last Day: Physical hydrogels Structure and chemistry Toda polyelectrolyte hydrogels, complexes, and coacervates rolyte multilayer theory of swelling in ionic hydrogels Reading S.K. De et aL., 'Equilibrium swelling and kinetics of pH-responsive hydrogels: Models experiments, and simulations

Lecture 6: Biodegradable Polymers for Tissue Engineering Last time: enzymatic degradation of solid polymers Engineering biological recognition of polymers Toda Designing polymers for tissue engineering Reading

Lecture 7: Hydrogel Biomaterials: Structure and Physical Chemistry Last Day: programmed/regulated/multifactor controlled release for drug delivery and tissue engineering