realized that the immune system could go awry and, instead of reacting against foreign antigens, could focus its attack on self-antigens. He termed this con- dition\horror autotoxicus \We now understand that while mechanisms of self-tolerance normally protect an individual from potentially self-reactive lymphocytes, there are failures They result in an inappropriate response of the immune system against self-components termed autoimmunity In the 1960s, it was believed that all self-reactive lymphocytes

PLANT TISSUE CULTURE is a blanket term for the in vitro cultivation of all plant parts under aseptic conditions. \plan t tissue culture\ is used as a blanket term for protoplast, cell, tissue and organ culture under aseptic conditions

Beginning Visual Basic 2005 Published b Wiley Publishing, Inc. 10475 Crosspoint Boulevard Indianapolis, IN 46256 www.wiley.com Copyright 2006 by Wiley Publishing, Inc., Indianapolis, Indiana Published simultaneously in Canada

susceptible host, a series of coordinated events must rcumvent both innate and adaptive immunity. One of the first and most important features of host innate immunity is the barrier provided by the epithelial surfaces of the skin and the lining of the gut. The difficulty of penetrat- ing these epithelial barriers ensures that most pathogens never gain productive entry into the host. In addition to pro viding a physical barrier to infection, the epithelia also pro duce chemicals that are useful in

Content 1. SERI Introduction 2. The Chinese Objective of RE 3. Solar Energy Resources in Yunnan 4. Photovoltaic Utilization 5. Solar Thermal Utilization

effector molecules that act to remove antigen b ren various mechanisms described in previous chap es antigen without A Second Exposure to Poison Oak May Result in Delayed-Type Hypersensitivity Gell and Coombs Classification IgE-Mediated (Type I) Hypersensitivity Antibody-Mediated Cytotoxic(Type) Hypersensitivity aImmune Complex-Mediated (Type Ill) Hypersensitivity

part of the body to another. This is espe- ially true of lymphocytes, which circulate ly in the blood and lymph and, in common with at sites o Lymphocytes Attached to the Surface of a High-Endothelial Venule sLymphocyte Recirculation Cell-Adhesion Molecules Neutrophil Extravasation Lymphocyte Extravasation Chemokines-Key Mediators of Inflammation Other Mediators of Inflammation The Inflammatory Process

of the humoral branch of the immune system Research on complement began in the 1890s, when Jules bordet at the institut pasteur in paris showed that sheep antiserum to the bacterium vibrio cholerae caused lysis of the bacteria and that heating the antiserum destroyed its bacteriolytic activity. Surprisingly, the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibodies directed a The Functions of Complement

Announcement \Chapter 8 Enzymes: Basic Concepts and Kinetics\ in Lubert Stryer's \Biochemistry\ (Fourth Edition) will be used as my major lecture material, which is available for you to Xerox from your TAs. Chapter 8 in Lehninger's“ Principles of Biochemistry can be used as a reference

ENZYMES ARE HIGHLY SPECIFIC Enzymes are highly specific both in the reaction catalyzed and in their choice of reactants, which are called substrales. An enzyme usually cata- lyzes a single chemical reaction or a set of closely related reactions. Side