Revision(Lesson 1-3) I Expressions Directions: Choose the correct English expressions of Chinese terms in the column A from column B Column a

Course Information: Business Negotiation Lecture day/Time: Wednesday 10: 15 Lecture Building/Room: Room 616, Library Building, Yuquan Campus Instructor Information: Yang Min/ Rosemary Course description The course introduces the basic concepts and practice of

Preface Veterinary Clinical Pathology: Veterinary Laboratory medicine Include: 1 Clinical Hematology 2 Clinical biochemistry 3 Clinical cytology 4 Clinical microbiology 5 Clinical parasitology 6 Clinical toxicology

Section 1 Bacteria Section 2 Actinomycetes Section 3 Cyanobacteria Section 4 Archaeobacteria Section 5 Other prokaryotes

Outline Distance Matrix Methods Neighbor-Joining Method and Related Neighbor Methods Maximum Likelihood Parsimony Branch and bound Heuristic Seaching Consensus Trees Software(PHYLIP, PAUP)

What is a genome? 123456789101112 13141516171819202122XY A genome is NoT a bag of proteins

Review of markov models DNA Evolution CpG Island HMM The viterbi algorithm Real World HMMs Markov models for dna evolution Ch. 4 of Mount

Outline Brief review of protein structure chou -Fasman- predictions Garnier, Osguthorpe and Robson Helical wheels and hydrophobic moments Neural networks Nearest neighbor methods Consensus prediction approaches

Review -Homology Modeling Identify a protein with similar sequence for which a structure has been solved (the template) Align the target sequence with the template Use the alignment to build an approximate structure for the target

1. Grow crystals-structure determination by X-ray crystallography relies on the repeating structure of a crystalline lattice 2. Collect a diffraction pattern-periodically spaced atoms in the crystal give specific\spots\where x-rays interfere constructively