PROTACS: CHIMERIC MOLECULES TO TARGET PROTEINS FOR UBIQUITINATION AND (taken from KM Sakamoto, Mol. Genetics and Metabolism 77(2002)44-56) target targettargettarget target target target target target To circumvent the problem of transducing cells at

Reversible ligation of Ubiquitin and Ubls to other proteins. Figure by MIT OCW. After Figure 1 in Hochstrasser M. Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol. 2000 Aug:

Contents Inter-temporal preferences Two periods Several periods · Asset market CAPM -APT Complete market Pure arbitrage

CONTENT Wa and demand law From preferences to utility Utility maximization EXpenditure minimization

Preference and Choice Content: Preference and rationality The rule of choice Budget Demand function WAand demanded law

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An Example Consider the following two cases

Centripetal Acceleration UCM results in acceleration: ← Magnitude a=vr= since=