(2)Explain how to detect nonlinearkinetics using AUCversusdosesplots. (3)Learn to apply Michaelis-Menten equation and graphical methods to calculateV.x and Kw. 2.教学重难点 The necessity to study Nonlinear Pharmacokinetics,how to determine Nonlinear Pharmacokinetics,the properties of Nonlinear Pharmacokinetics,calculation of related PK parameters. 3.教学内容 Saturable Enzymatic Elimination Processes,Drug Elimination by Capacity-Limited Pharmacokinetics:One- Compartment Model,IV Bolus Injection,drugs distributed as one-compartment model and eliminated by nonlinear pharmacokinetics,chronopharmacokinetics and time-dependent pharmacokinetics,bioavailability of drugs that follow nonlinear pharmacokinetics,nonlinear pharmacokinetics due to drug-protein binding, potential reasons for unsuspected nonlinearity,dose-dependent pharmacokinetics. 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第十章Physiologic Drug Distribution and Protein Binding 1.教学目标 (1)Describe the physiology of drugdistribution in the body. (2)Explain how drug distribution isaffected by blood flow,protein,and tissue binding.(2) Explain how to detect nonlinearkinetics using AUCversusdosesplots. (3) Learn to apply Michaelis–Menten equation and graphical methods to calculateVmax and KM. 2.教学重难点 The necessity to study Nonlinear Pharmacokinetics, how to determine Nonlinear Pharmacokinetics, the properties of Nonlinear Pharmacokinetics, calculation of related PK parameters. 3.教学内容 Saturable Enzymatic Elimination Processes, Drug Elimination by Capacity-Limited Pharmacokinetics: One￾Compartment Model, IV Bolus Injection, drugs distributed as one-compartment model and eliminated by nonlinear pharmacokinetics, chronopharmacokinetics and time-dependent pharmacokinetics, bioavailability of drugs that follow nonlinear pharmacokinetics, nonlinear pharmacokinetics due to drug–protein binding, potential reasons for unsuspected nonlinearity, dose-dependent pharmacokinetics. 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions. 第十章 Physiologic Drug Distribution and Protein Binding 1.教学目标 (1) Describe the physiology of drugdistribution in the body. (2) Explain how drug distribution isaffected by blood flow, protein,and tissue binding