(3)Describe how drug distributioncan affect the apparent volumeof distribution. (4)Explain how volume ofdistribution,drug clearance,and half-life can be affected by protein binding. 2.教学重难点 The physiology of drugdistribution in the body,factors affect drug distribution,the definition and significance of drug protein binding in vivo,the relationship between drug distribution,drug clearance and half-life of elimination. 3.教学内容 Physiologic factors of distribution,apparent volume distribution,protein binding of drugs,effect of protein binding on the apparent volume of distribution,relationship of plasma drug-protein binding to distribution and elimination,determinants of protein binding,kinetics of protein binding. 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第十-章Drug EI imination and Hepatic Clearance 1.教学目标 (1)Describe the pathways for drugelimination in the body.(3) Describe how drug distributioncan affect the apparent volumeof distribution. (4) Explain how volume ofdistribution, drug clearance,and half-life can be affected by protein binding. 2.教学重难点 The physiology of drugdistribution in the body, factors affect drug distribution, the definition and significance of drug protein binding in vivo, the relationship between drug distribution, drug clearance and half-life of elimination. 3.教学内容 Physiologic factors of distribution, apparent volume distribution, protein binding of drugs, effect of protein binding on the apparent volume of distribution, relationship of plasma drug–protein binding to distribution and elimination, determinants of protein binding, kinetics of protein binding. 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions. 第十一章 Drug Elimination and Hepatic Clearance 1.教学目标 (1) Describe the pathways for drugelimination in the body