Inductive effects诱导效应 Inductive effects are strongly dependent on distance.The effect of the halogen decreases as the distance increases. FCH2CO2H>CICH2CO2H>BrCH2CO2H>CH3CO2H pKa 2.59 2.87 2.90 4.76 CICCO,H>CICHCO2H>CICH2CO,H>CHCO2H pKa 0.64 1.26 2.87 4.76 CO2H pKa 2.86 4.05 4.52 FCH2CO2H > ClCH2CO2H > BrCH2CO2H > CH3CO2H Cl3CCO2H > Cl2CHCO2H > ClCH2CO2H > CH3CO2H CO2H Cl CO2H Cl CO2H Cl > > pKa pKa pKa 2.59 2.87 2.90 4.76 0.64 1.26 2.87 4.76 2.86 4.05 4.52 Inductive effects 诱导效应 ◼Inductive effects are strongly dependent on distance. The effect of the halogen decreases as the distance increases