天然产物化学促进有机化学的发展 天然产物化学促进有机化学的发展 20世纪最作大的化学意 ” m Inrer.Ed.2011.50(5 p12412247 ard 1965 and 1981 NP. 天然产物化学促进有机化学的发展 天然产物化学促进有机化学的发展 Syuthesis Simulation 人 Lo 岩沙海芽毒素PTX 划时代的天格产全合成 经 3 N N N N NH2 O Co O NH2 NH2 O H2N O H H2N O NH O O O P O O O OH N N CN HO O NH2 Albter Eschenmoser 瑞士联邦理工学院 Swiss Federal Institute of Technology Angew. Chem. Inter. Edi. 2011, 50(52): 12412-12472. 天然产物化学促进有机化学的发展 VB12 Woodward 20世纪最伟大的化学家 Woodward and Mark Wuonola on March 17, 1976, the day that the synthesis of Vitamin B12 was completed. Woodward 1965 and Hoffmann 1981 NP. Natural product synthesis has indeed been the impetus for many fundamental discoveries (Vitamin B12-----Pericyclic Reaction and Woodward-Hoffman Rule) 天然产物化学促进有机化学的发展 Roald Hoffmann Retro-synthetic Analysis 1990 天然产物化学促进有机化学的发展 Prostaglandins Longifolene E. J. Corey OCSS: Organic Chemical Synthesis Simulation COOH HO OH OH O O O O HO O O HO O OH H OH H H Ginkgolide C Corey–Woodward–Hoffmann rules? 将计算机图形处理技术引入 有机化学信息系统管理 ChemDraw、SciFinder 2004普利斯特里奖Priestley Medal 天然产物化学促进有机化学的发展 岩沙海葵毒素 PTX Yoshito Kishi 岸 義人 O OH OH OH HO O OH OH O HO OH OH OH OH O OH HO OH OH OH OH O O O OH NH2 HO OH O O O OH OH OH HO OH OH OH HO HN O NH OH O OH OH OH OH OH HO OH OH OH OH OH OH OH 21 P-PhD and PhD Students spend more than 8 years in 1992 N O H3C 1828 O OH OH HO HO OH 1890 1917 1956 W. S. Johnson 1971 1973 1977 2007 Phil S. Baran AgNCO H2N NH2 O NH4Cl + AgCl Wohler 划时代的天然产物全合成