天然产物全合成诺贝尔化学奖候选人 马钱子碱一最复杂的天然小分子之 44 天然产物全合成诺贝尔化学奖候选人 Barry M. Trost Paul A. Wender Baran, P. S Steven V. Ley Samuel Danishefsky K. C. Nicolaou Yoshito Kishi Atom economy Science 1991, 254, 1471 Step economy Redox economy 1993 J. Am. Chem. Soc., 2008, 130:17938-54 马钱子碱—最复杂的天然小分子之一 Is there no end to the total syntheses of strychnine? Isolation 1918，Structure determined by Robinson and Leuchs in 1947. First Synthesized by Woodward in 1954. 马钱子碱(strychnine) 兴奋剂罪恶史之最初：1904年粉墨登场 If I can not make it I take it N N H H H O H H O