Approaches to identifying NOEs ·H-1 H NOESY 2D H←◆H 3D H←◆H←◆H 15N-or 13C-dispersed H-H NOESY 3D H ◆H H H 15N 13C 4D H ◆ H H←◆ H H◆◆ H 15N 13C 13C 13C 15N 15N 15 15 Approaches to identifying NOEs • 15N- or 13C-dispersed 1H- 1H NOESY 3D 4D 2D 1H 1H 3D 1H 1H 1H • 1H- 1H NOESY