Clinical features Cardiovascular signs t Impaired myocardium contraction t bradycardia t Diminished cardiac output t ECG: low voltage of QRS, P, t waves t Pericardial effusion Coronary artery disease Cardiac angina(Replacement therapy aggravateClinical Features Cardiovascular signs  Impaired myocardium contraction  Bradycardia  Diminished cardiac output  ECG: low voltage of QRS, P, T waves  Pericardial effusion  Coronary artery disease  Cardiac angina(Replacement therapy aggravate )