Question 5 You are an immunologist who wants to make the big bucks. you decide to leave the world of science and get a job as a script-consultant on a new medical drama(Er-like) show. You test the writers with a few questions to see just how much they know a)Compare how macrophages and B cells recognize antigen b)Compare how macrophages and B cells present antigenic peptides(epitopes) They present epitopes exactly the same way on their MHC ll molecules on the surface c)Macrophages and B cells present antigens to cells (Fill in blanks.) d) Name 2 components of the innate or nonspecific immune system Below are short descriptions given to you by the writers of scenarios in the early Scenario #1 One of the characters on the show is diagnosed with leukemia, a cancer of the blood system. She is very sick until her boyfriend bravely agrees to donate his bone marrow e)You tell the writers that the bone marrow transplant from the boyfriend is unlikely to be successful. give the reason and the molecular basis for why Because of the different major histocompatability molecules the marrow will be rejected Scenario #2 The leading doctor gives birth to a baby boy. After some time, the child shows no acquired or specific immune response and is diagnosed with a rare disorder, Severe Combined Immune Deficiency(SCID), and as a result the boy must live in a germ-free environment. Several causes of SCid have been described and are listed below f) For each cause, indicate which of the following branches of immune system are affected ( Cellular=Cell-Mediated) Cause Cell-Mediated. humoral or both T cells fail to develop DNA recombination deficiency absence of mhc class i molecules Lack of mhc class ii molecules8 Question 5 You are an immunologist who wants to make the big bucks. You decide to leave the world of science and get a job as a script-consultant on a new medical drama (ER-like) show. You test the writers with a few questions to see just how much they know. a) Compare how macrophages and B cells recognize antigen. b) Compare how macrophages and B cells present antigenic peptides (epitopes). They present epitopes exactly the same way on their MHC II molecules on the surface. c) Macrophages and B cells present antigens to ________ _____-cells. (Fill in blanks.) d) Name 2 components of the innate or nonspecific immune system. _______________________ _________________________ Below are short descriptions given to you by the writers of scenarios in the early episodes. Scenario #1 One of the characters on the show is diagnosed with leukemia, a cancer of the blood system. She is very sick until her boyfriend bravely agrees to donate his bone marrow. The bone marrow transplant is successful and our character lives! e) You tell the writers that the bone marrow transplant from the boyfriend is unlikely to be successful. Give the reason and the molecular basis for why. Because of the different major histocompatability molecules the marrow will be rejected. Scenario #2 The leading doctor gives birth to a baby boy. After some time, the child shows no acquired or specific immune response and is diagnosed with a rare disorder, Severe Combined Immune Deficiency (SCID), and as a result the boy must live in a germ-free environment. Several causes of SCID have been described and are listed below. f) For each cause, indicate which of the following branches of immune system are affected. (Cellular =Cell-Mediated) Cause Cell-Mediated, Humoral or Both T cells fail to develop DNA recombination deficiency Absence of MHC class I molecules Lack of MHC class II molecules