504|李东,等:国内外营养型脂肪乳剂研究进展 lo Rodriguez B, Wilhelm A, Kokko K E Lipid emulsion use precluding dy on the efficacy and safety of an n-3 fatty acid enriched intravenous renal replacement therapy!]. J Emerg Med, 2014, 47(6): 635-637 fat emulsion in postsurgical gastric and colorectal cancer patients 张才华,李宁,王新颖,等, Lippus脂肪乳对胃肠恶性肿瘤患者术 NrJ,2015,14(2)9 后营养状况和早期炎性反应的影响门中华胃肠外科杂志,2012,(22] Boisrame- Helms j, Toti F, Hasselmann M,eal. Lipid emulsions for 15(5)448-451 parenteral nutrition in critical illness[]. Prog Lipid Res, 2015, 60(10) [12 Macia-Botejara E, Moran-Penco J M, Espin-Jaime M T, et al. Brain lipid composition in rabbits after total parenteral nutrition with two 23 Nandivada P, Cowan E, Carlson S J, et al. Mechanisms for the effects 3]张蓬华,梁俊,张静,等.水飞蓟宾脂眆乳的制备、性质及体外释药 associated liver disease]. Prostaglandins Leukotrienes Essent Fatty 研究[中国药师,2013,17(4)586-571 Acids,2013,89(4)153-158 14 Kreymann G. What lipid emulsion should be administered to ICU241梁珊珊,陈海燕.肠内营养乳剂在胃癌患者术前肠道准备中的应用 lents? P). Anesteziol Reanimatol, 2014(3): 46-49 门上海护理,2013,13(3)22-25. 5 Gramlich L, Meddings l, Alberda C,etal. Essential fatty acid(25]杨丽霞,全东琴,王涛.丁酸氯维地平静脉脂眆乳剂的质量评价 ficiency in 2015: The impact of novel intravenous lipid emulsions 现代生物医学进展,2013,13(7):1272-127 J Parenter Enteral Nutr, 2015, 39(S1): 61S-66S 26赵绘绘,汤鲁宏注射用高纯度蛋黄卵磷脂制备新工艺的研究 l16 Ren T, Cong L, Wang Y, et al. Lipid emulsions in parenteral nutritio 天然产物研究与开发,2014,26(4)564-569 current applications and future developments). Expert Opin Drug7刘竹青,陈有亮.乙酸乙酯萃取法精制蛋黄磷脂的工艺研究中 Delv,2013,l0(1):1533-1550. 国油脂,2013,38(3):55-57 17 Hippalgaonkar K, Majumdar S, Kansara V Injectable lipid emulsions. 28 Bou R, Cofrades S, Jimenez-Colmenero F. Physicochemical properties advancements, opportunities and challenges]. AAPS PharmScilech, and riboflavin encapsulation in double emulsions with different lipid 2010,114):1526-1540 urcesp] Food Sci Technol, 2014, 59(2): 621-628 118] Stapleton R D, Martin J M, Mayer K. Fish oil in critical illne 129卢隆桂,谢依侨,司徒少金,等.注射用尼莫地平脂肪乳的制备及 mechanisms and clinical applications P. Crit Care Clin, 2010, 26(3) 质量研究广东药学院学报,2014,303):265-268 501-514. 0 Xiang J, Liu F G, Fan R, et al. Physicochemical stability of citral 9 Berthold K, Olivier G. Fish oil containing intravenous lipid emulsions emulsions stabilized by milk proteins(lactoferrin, a-lactalbumin. in parenteral nutrition-associated cholestatic liver disease). Curr Opin B-lactoglobulin)and beet pectin[ ]. Colloids Surf A Physicochem Eng Clin Nutr Metab Care, 2010, 13(3): 321-326 Asp,2015,487020):104112. 20 Tian H L, Yao XR, Zeng R, er al. Safety and efficacy of a new parenteral 31 Fell G L, Nandivada P, Gura K M, et al. Intravenous lipid emulsions in lipid emulsion(SMOF) for surgical patients: a systematic review and parenteral nutrition[]. Adv Nutr, 2015, 6(5): 600-610 meta-analysis of randomized controlled trials(). Nutr Rev,2013.7(12)132赵明明,苏敏,唐星载药脂肪乳注射液的研究进展沈阳药科 815-82 大学学报,2010,27(12):1014102 21 Ma CJ, wuJ M, Tsai H L, et al. Prospective double-blind randomized 专家介绍]甘莉:主要从事功能性纳米载体的设计及其在眼组织转运和生物效应机制的研究;新型纳米制剂(脂 肪乳、脂质体等)的开发及产业化研究。目前,主持或参与了国家973计划、863计划(2007A021604)、国家自 然科学基金(81102387)、上海市科委(11zR144100等多项项目,在 Biomaterials、 Drug Discovery Today国内 外一流学术期刊发表论文20余篇。在新制剂的研发和产业化推进方面,完成了H205眼用乳剂、环孢素A眼用乳剂 前列地尔脂肪乳和磷酸奥司他韦胶囊等近10项新制剂的开发,先后协助企业完成了眼用乳剂及注射乳剂等3条生 产线的建立。申请新型专利12项,其中PCT专利1项,获授权专利6项。获2015年中国产学研合作创新个人奖 2012年中国药学会“第十一届全国青年药学工作者最新科研成果交流会”优秀论文三等奖。中科院青年创新促进会 会员,中科院上海药物所首届“新星计划A类”人才。国家食品药品监督管理局新药评审专家。 Prog Pharm Sci Jul 2016 PPS 鈞学进展2016年7月第40卷第7期504 李东 , 等：国内外营养型脂肪乳剂研究进展 Prog Pharm Sci Jul. 2016 Vol. 40 No. 7 2016 年 7 月 第 40 卷 第 7 期 Rodríguez B, Wilhelm A, Kokko K E. Lipid emulsion use precluding renal replacement therapy[J]. J Emerg Med, 2014, 47(6): 635-637. 张才华 , 李宁 , 王新颖 , 等 . Lipoplus 脂肪乳对胃肠恶性肿瘤患者术 后营养状况和早期炎性反应的影响 [J]. 中华胃肠外科杂志 , 2012, 15(5): 448-451. Maciá-Botejara E, Morán-Penco J M , Espín-Jaime M T, et al. Brain lipid composition in rabbits after total parenteral nutrition with two different lipid emulsions [J]. Nutrition, 2013, 29(1): 313-317. 张蓬华 , 梁俊 , 张静 , 等 . 水飞蓟宾脂肪乳的制备、性质及体外释药 研究 [J]. 中国药师 , 2013, 17(4): 586-571. Kreymann G. What lipid emulsion should be administered to ICU patients?[J]. Anesteziol Reanimatol, 2014(3): 46-49. Gramlich L, Meddings L, Alberda C, et al. Essential fatty acid deficiency in 2015: The impact of novel intravenous lipid emulsions[J]. J Parenter Enteral Nutr, 2015, 39(S1): 61S-66S. Ren T, Cong L,Wang Y, et al. Lipid emulsions in parenteral nutrition: current applications and future developments[J]. Expert Opin Drug Deliv, 2013, 10(11): 1533-1550. Hippalgaonkar K, Majumdar S, Kansara V. Injectable lipid emulsions￾advancements, opportunities and challenges[J]. AAPS PharmSciTech, 2010, 11(4): 1526-1540. Stapleton R D, Martin J M , Mayer K. Fish oil in critical illness: mechanisms and clinical applications [J]. Crit Care Clin, 2010, 26(3): 501-514. Berthold K, Olivier G. Fish oil containing intravenous lipid emulsions in parenteral nutrition-associated cholestatic liver disease[J].Curr Opin Clin Nutr Metab Care, 2010, 13 (3): 321-326. Tian H L,Yao X R, Zeng R, et al. Safety and efficacy of a new parenteral lipid emulsion (SMOF) for surgical patients: a systematic review and meta-analysis of randomized controlled trials[J]. Nutr Rev, 2013, 71(12): 815-821. Ma C J, Wu J M, Tsai H L, et al. Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients[J]. Nutr J, 2015, 14(2): 9. Boisramé-Helms J, Toti F, Hasselmann M, et al. Lipid emulsions for parenteral nutrition in critical illness[J]. Prog Lipid Res, 2015, 60(10): 1-16. Nandivada P, Cowan E, Carlson S J, et al. Mechanisms for the effects of fish oil lipid emulsions in the management of parenteral nutrition￾associated liver disease[J].Prostaglandins Leukotrienes Essent Fatty Acids, 2013, 89(4): 153-158. 梁珊珊 , 陈海燕 . 肠内营养乳剂在胃癌患者术前肠道准备中的应用 [J]. 上海护理 , 2013, 13(3): 22-25. 杨丽霞 , 全东琴 , 王涛 . 丁酸氯维地平静脉脂肪乳剂的质量评价 [J]. 现代生物医学进展 , 2013, 13(7): 1272-1277. 赵绘绘 , 汤鲁宏 . 注射用高纯度蛋黄卵磷脂制备新工艺的研究 [J]. 天然产物研究与开发 , 2014, 26(4): 564-569. 刘竹青 , 陈有亮 . 乙酸乙酯萃取法精制蛋黄磷脂的工艺研究 [J]. 中 国油脂 , 2013, 38(3): 55-57. Bou R, Cofrades S, Jiménez-Colmenero F. Physicochemical properties and riboflavin encapsulation in double emulsions with different lipid sources[J]. Food Sci Technol, 2014, 59(2): 621-628. 卢隆桂 , 谢依侨 , 司徒少金 , 等 . 注射用尼莫地平脂肪乳的制备及 质量研究 [J]. 广东药学院学报 , 2014, 30(3): 265-268. Xiang J, Liu F G, Fan R, et al. Physicochemical stability of citral emulsions stabilized by milk proteins (lactoferrin, α-lactalbumin, β-lactoglobulin) and beet pectin[J].Colloids Surf A Physicochem Eng Asp, 2015, 487(20): 104-112. Fell G L, Nandivada P, Gura K M, et al. Intravenous lipid emulsions in parenteral nutrition[J]. Adv Nutr, 2015, 6(5): 600-610. 赵明明 , 苏敏 , 唐星 . 载药脂肪乳注射液的研究进展 [J]. 沈阳药科 大学学报 , 2010, 27(12): 1014-1022. [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28] [29] [30] [31] [32] [ 专家介绍 ] 甘莉：主要从事功能性纳米载体的设计及其在眼组织转运和生物效应机制的研究；新型纳米制剂（脂 肪乳、脂质体等）的开发及产业化研究。目前，主持或参与了国家 973 计划、863 计划（2007AA021604）、国家自 然科学基金（81102387）、上海市科委（11ZR1444700）等多项项目，在 Biomaterials、Drug Discovery Today 国内 外一流学术期刊发表论文 20 余篇。在新制剂的研发和产业化推进方面，完成了 H205 眼用乳剂、环孢素 A 眼用乳剂、 前列地尔脂肪乳和磷酸奥司他韦胶囊等近 10 项新制剂的开发，先后协助企业完成了眼用乳剂及注射乳剂等 3 条生 产线的建立。申请新型专利 12 项，其中 PCT 专利 1 项，获授权专利 6 项。获 2015 年中国产学研合作创新个人奖， 2012 年中国药学会“第十一届全国青年药学工作者最新科研成果交流会”优秀论文三等奖。中科院青年创新促进会 会员，中科院上海药物所首届“新星计划 A 类”人才。国家食品药品监督管理局新药评审专家