革山院 Definition Chronic renal failure(Crf) a pathophysiologic process with multiple causes that lasts >3 months and results in progressive, irreversible attrition of the number and function of nephrons Typically corresponds to CKd stages 3-5 Frequently leads to end-stage renal disease (ESrD)Definition • Chronic renal failure (CRF) – A pathophysiologic process with multiple causes that lasts > 3 months and results in progressive, irreversible attrition of the number and function of nephrons – Typically corresponds to CKD stages 3–5 – Frequently leads to end-stage renal disease (ESRD)