IgE response is a local event site of allergen entry local synthesis results in sensitization of local mast cells spillover of IgE enters circulation and sensitizes mast cells and basophils systemically IgE response is a local event ◼ site of allergen entry ◼ local synthesis results in sensitization of local mast cells ◼ spillover of IgE enters circulation and sensitizes mast cells and basophils systemically