Characteristics of IgE Heat labile ■Fe binding destroyed by heating at56°Cfor 30 min antigen binding is not lost Half-life serum half-life is 2 1/2 days (IgG is 21 days) mast cell bound half-life is 12 weeksCharacteristics of IgE ◼ Heat labile ◼ Fc binding destroyed by heating at 56°C for 30 min ◼ antigen binding is not lost ◼ Half-life ◼ serum half-life is 2 1/2 days (IgG is 21 days) ◼ mast cell bound half-life is 12 weeks