S Pyogenes Virulence Factors Streptokinase digest fibrin and other proteins Hyaluronidase breaks down hyaluronic acid in connective tissue allowing spread Streptodornase are DNAses C5a Peptidase are used to minimize influx of neutrophils early in infectionS. Pyogenes Virulence Factors – Streptokinase digest fibrin and other proteins – Hyaluronidase breaks down hyaluronic acid in connective tissue allowing spread – Streptodornase are DNAses – C5a Peptidase are used to minimize influx of neutrophils early in infection