5 Pathogenesis Immunity Virus enters hepatocytes via blood Immune response(cytotoxic T cell) to viral antigens expressed on hepatocyte cell surface responsible for clinical syndrome 5 become chronic carriers(HBsAg> 6 months) Higher rate of hepatocellular ca in chronic carriers, especially those who are"antigen posItive Hepatitis B surface antibody likely confers lifelong immunity (gG anti-HBS) Hepatitis B e Ab indicates low transmissibility5、Pathogenesis & Immunity • Virus enters hepatocytes via blood • Immune response (cytotoxic T cell) to viral antigens expressed on hepatocyte cell surface responsible for clinical syndrome • 5 % become chronic carriers (HBsAg> 6 months) • Higher rate of hepatocellular ca in chronic carriers, especially those who are “e” antigen positive • Hepatitis B surface antibody likely confers lifelong immunity (IgG anti-HBs) • Hepatitis B e Ab indicates low transmissibility