Thr NEW ENGLAND JOURNAL f MEDICINE 152281 52262 ()up N ENGLJ MED NEJM.ORC Co→ nal us Copyngnt 2020 Mas8 n engl j med nejm.org The new england journal o f medicine Table 2. Radiographic and Laboratory Findings.* Variable All Patients (N=1099) Disease Severity Presence of Composite Primary End Point Nonsevere (N=926) Severe (N=173) Yes (N=67) No (N=1032) Radiologic findings Abnormalities on chest radiograph — no./total no. (%) 162/274 (59.1) 116/214 (54.2) 46/60 (76.7) 30/39 (76.9) 132/235 (56.2) Ground-glass opacity 55/274 (20.1) 37/214 (17.3) 18/60 (30.0) 9/39 (23.1) 46/235 (19.6) Local patchy shadowing 77/274 (28.1) 56/214 (26.2) 21/60 (35.0) 13/39 (33.3) 64/235 (27.2) Bilateral patchy shadowing 100/274 (36.5) 65/214 (30.4) 35/60 (58.3) 27/39 (69.2) 73/235 (31.1) Interstitial abnormalities 12/274 (4.4) 7/214 (3.3) 5/60 (8.3) 6/39 (15.4) 6/235 (2.6) Abnormalities on chest CT — no./total no. (%) 840/975 (86.2) 682/808 (84.4) 158/167 (94.6) 50/57 (87.7) 790/918 (86.1) Ground-glass opacity 550/975 (56.4) 449/808 (55.6) 101/167 (60.5) 30/57 (52.6) 520/918 (56.6) Local patchy shadowing 409/975 (41.9) 317/808 (39.2) 92/167 (55.1) 22/57 (38.6) 387/918 (42.2) Bilateral patchy shadowing 505/975 (51.8) 368/808 (45.5) 137/167 (82.0) 40/57 (70.2) 465/918 (50.7) Interstitial abnormalities 143/975 (14.7) 99/808 (12.3) 44/167 (26.3) 15/57 (26.3) 128/918 (13.9) Laboratory findings Median Pao2:Fio2 ratio (IQR)† 3.9 (2.9–4.7) 3.9 (2.9–4.5) 4.0 (2.8–5.2) 2.9 (2.2–5.4) 4.0 (3.1–4.6) White-cell count Median (IQR) — per mm3 4700 (3500– 6000) 4900 (3800–6000) 3700 (3000–6200) 6100 (4900– 11,100) 4700 (3500– 5900) Distribution — no./total no. (%) >10,000 per mm3 58/978 (5.9) 39/811 (4.8) 19/167 (11.4) 15/58 (25.9) 43/920 (4.7) <4000 per mm3 330/978 (33.7) 228/811 (28.1) 102/167 (61.1) 8/58 (13.8) 322/920 (35.0) Lymphocyte count Median (IQR) — per mm3 1000 (700–1300) 1000 (800–1400) 800 (600–1000) 700 (600–900) 1000 (700–1300) Distribution — no./total no. (%) <1500 per mm3 731/879 (83.2) 584/726 (80.4) 147/153 (96.1) 50/54 (92.6) 681/825 (82.5) The New England Journal of Medicine Downloaded from nejm.org at SOUTHERN MEDICAL UNIVERSITY on March 6, 2020. For personal use only. No other uses without permission. Copyright © 2020 Massachusetts Medical Society. All rights reserved