2) Types of renal tubular dysfunction O Dysfunction of reabsorption Proximal convoluted tubule: glucosuria, phosphuria aminoaciduria, Na and h,o retention renal tubular acidosis 2 Dysfunction of concentration and dilution Henle's (medullary) loop and collecting tubule polyuria, Isosthenuria(isotonic), Hyposthenuria(hypotonic) (3 Acid-base Disturbances Proximal tubule(secrete H, NH4, NH3; reabsorb HCO3) Medullary loop(reabsorb b HCO3 and NH3 Distal tubule(secrete H) 1212 ① Dysfunction of reabsorption Proximal convoluted tubule: glucosuria, phosphuria, aminoaciduria, Na+ and H2O retention, renal tubular acidosis ③ Acid-base Disturbances Proximal tubule (secrete H+ , NH4 + , NH3 ; reabsorb HCO3 – ); Medullary loop (reabsorb b HCO3 – and NH3 ) Distal tubule (secrete H+ ) ② Dysfunction of concentration and dilution Henle’s (medullary) loop and collecting tubule: polyuria, Isosthenuria (isotonic), Hyposthenuria (hypotonic) 2) Types of renal tubular dysfunction