2教学重难点 The difference between innate and adaptive immune system and why we need both systems The structural and functional difference between MHC class I and class II molecules The characteristic structure and function of the five main classes of antibodies 3.教学内容 3.1.Overview of adaptive immunity Similarities and differences between innate and adaptive immune system 3.2.Antigens and antigenicity Definitions of antigen,antigenicity,immunogen,immunogenicity and epitope The origin of antigens Factors affecting antigenicity (size,complexity and molecular shape)and their applications in inducing immune responses The structure and function of different types of antigens such as hapten,alloantigen, superantigen,allergen and autoantigen 3.3.The Major Histocompatibility Complex(MHC)and antigen presentation Structure and function of MHC Class I and Class II molecules Expression pattern of MHC molecules The origin of diversity of MHC molecules Antigen presenting cells The endogenous pathway of antigen processing and presentation The exogenous pathway of antigen processing and presentation 3.4.Antibody The structure of antibodies (light chains,heavy chains,complementarity-determining region) The structure.function.distribution and relative abundance of the five major classes of antibodies(IgG,IgA,IgM,IgD,IgE) 4.教学方法 4.1.Multimedia PowerPoint slides for content display Video clip about adaptive immune system Video clip about antibody structure 4.2.Teacher-student interaction On-screen multiple-choices quiz at the end of each section during the class Discussion about the roles of MHC molecules the potential outcome during a virus pandemic 5.教学评价 课后问题2.教学重难点 • The difference between innate and adaptive immune system and why we need both systems • The structural and functional difference between MHC class I and class II molecules • The characteristic structure and function of the five main classes of antibodies 3.教学内容 3.1. Overview of adaptive immunity • Similarities and differences between innate and adaptive immune system 3.2. Antigens and antigenicity • Definitions of antigen, antigenicity, immunogen, immunogenicity and epitope • The origin of antigens • Factors affecting antigenicity (size, complexity and molecular shape) and their applications in inducing immune responses • The structure and function of different types of antigens such as hapten, alloantigen, superantigen, allergen and autoantigen 3.3. The Major Histocompatibility Complex (MHC) and antigen presentation • Structure and function of MHC Class I and Class II molecules • Expression pattern of MHC molecules • The origin of diversity of MHC molecules • Antigen presenting cells • The endogenous pathway of antigen processing and presentation • The exogenous pathway of antigen processing and presentation 3.4. Antibody • The structure of antibodies (light chains, heavy chains, complementarity-determining region) • The structure, function, distribution and relative abundance of the five major classes of antibodies (IgG, IgA, IgM, IgD, IgE) 4.教学方法 4.1. Multimedia • PowerPoint slides for content display • Video clip about adaptive immune system • Video clip about antibody structure 4.2. Teacher-student interaction • On-screen multiple-choices quiz at the end of each section during the class • Discussion about the roles of MHC molecules the potential outcome during a virus pandemic 5.教学评价 课后问题