Outline the overall phases in a specific immune response. Summarize the general features of adaptive/acquired immunity.How is adaptive immunity different from innate immunity? Define antigen and immunogen. What are the main categories of antigens based on their chemistry and function? How do shape,size and complexity contribute to antigenicity? What is major histocompatibility complex?Explain how it participates in immune reactions. Why do we need different pathways for antigen presentation? 第五章T cell development,.activation and differentiation(Yiran Zheng 1.教学目标 Know the basic steps involved in the T cell development Know the positive selection and negative selection steps in the T cell development and grasp the significance of having both screening Know signals required for T cell activation and the molecules involved Know the main subsets of T cells and their respective function 2.教学重难点 The mechanism of VDJ recombination Positive selection and negative selection in T cell development.The significance of having both positive selection and negative selection The signals required for T cell activation The collaboration of different molecules involved in the immune synapse for T cell activation 3教学内容 3.1.T cell development Overview of tissues and organs required for T cell development Early thymocyte development The origin of T cell receptor diversity o Multigene organization of Ig Genes o The mechanism of V(D)J recombination o Tcell receptor gene expression Overview of T cell development(double negative stages,double positive stage,single positive stage) Positive selection and its significance Negative selection and its significance The structure of T cell receptor(TCR) Lineage commitment:aBT cells and yT cells 3.2.T cell activation and differentiation T cell activation signal 1:TCR-MHC-peptide signaling• Outline the overall phases in a specific immune response. • Summarize the general features of adaptive/acquired immunity. How is adaptive immunity different from innate immunity? • Define antigen and immunogen. • What are the main categories of antigens based on their chemistry and function? • How do shape, size and complexity contribute to antigenicity? • What is major histocompatibility complex? Explain how it participates in immune reactions. • Why do we need different pathways for antigen presentation? 第五章 T cell development, activation and differentiation (Yiran Zheng) 1.教学目标 • Know the basic steps involved in the T cell development • Know the positive selection and negative selection steps in the T cell development and grasp the significance of having both screening • Know signals required for T cell activation and the molecules involved • Know the main subsets of T cells and their respective function 2.教学重难点 • The mechanism of VDJ recombination • Positive selection and negative selection in T cell development. The significance of having both positive selection and negative selection • The signals required for T cell activation • The collaboration of different molecules involved in the immune synapse for T cell activation 3.教学内容 3.1. T cell development • Overview of tissues and organs required for T cell development • Early thymocyte development • The origin of T cell receptor diversity o Multigene organization of Ig Genes o The mechanism of V(D)J recombination o T cell receptor gene expression • Overview of T cell development (double negative stages, double positive stage, single positive stage) • Positive selection and its significance • Negative selection and its significance • The structure of T cell receptor (TCR) • Lineage commitment: αβT cells and γδT cells 3.2. T cell activation and differentiation • T cell activation signal 1: TCR-MHC-peptide signaling