VIl From the preface to the third edition The first German edition of this book was al- Their intention was to cross the atlantic in their sailing boat. This was the last that wa ever heard of them and we have had to aban- Without the creative enthusiasm of Aga- menon Despopoulos, it is doubtful whether this book would have been possible; without his personal support it has not been easy to continue with the project. whilst keeping in mind our original aims, I have completely re vised the book, incorporating the latest adval in the field of physiology as well as the wel- edition, to whom I extend my thanks for their active interest in New York: Professor of Physiology at the buquerque, USA, until 1971: Wurzburg, Fall 1985 scientific adviser to CIBA-GEIGY. Basel.VII From the Preface to the Third Edition The first German edition of this book was already in press when, on November 2nd, 1979, Agamennon Despopoulos and his wife, Sarah Jones-Despopoulos put to sea from Bizerta, Tunisia. Their intention was to cross the Atlantic in their sailing boat. This was the last that was ever heard of them and we have had to abandon all hope of seeing them again. Without the creative enthusiasm of Agamennon Despopoulos, it is doubtful whether this book would have been possible; without his personal support it has not been easy to continue with the project. Whilst keeping in mind our original aims, I have completely revised the book, incorporating the latest advances in the field of physiology as well as the welcome suggestions provided by readers of the earlier edition, to whom I extend my thanks for their active interest. Würzburg, Fall 1985 Stefan Silbernagl Dr. Agamemnon Despopoulos Born 1924 in New York; Professor of Physiology at the University of New Mexico. Albuquerque, USA, until 1971; thereafter scientific adviser to CIBA-GEIGY, Basel