There are a limited number of catalytic mechanisms or factors that contribute to the remarkable performance of enzymes.These include the following: 1.Entropy loss in ES formation 2.Destabilization of ES due to strain, desolvation,or electrostatic effects 3.Covalent catalysis 4.General acid or base catalysis 5.Metal ion catalysis 6.Proximity and orientationThere are a limited number of catalytic mechanisms or factors that contribute to the remarkable performance of enzymes. These include the following: 1. Entropy loss in ES formation 2. Destabilization of ES due to strain, desolvation, or electrostatic effects 3. Covalent catalysis 4. General acid or base catalysis 5. Metal ion catalysis 6. Proximity and orientation