What's the significance of zwitterion property? Ionizable groups stabilize the pH value of the solution against external disturbances. Any ionizable group buffers the pH of the solution at pH value close to its pK. The buffering capacity of ionizable groups helps human maintain a constant in body fluid. A contribution to homeostatsis What’s the significance of zwitterion property? • Ionizable groups stabilize the pH value of the solution against external disturbances. • Any ionizable group buffers the pH of the solution at pH value close to its pK. • The buffering capacity of ionizable groups helps human maintain a constant in body fluid. A contribution to homeostatsis