1/26/2016 Salmonella entering intestinal epithelial cells as a result of ruffling. Flagella cel (c)Bacteria(purple)adhering to human skin e15m How Pathogens Penetrate Host Defenses Most pathogens invade host tissues to cause Learning Objectives disease. Explain how capsules and cell wall components Factors that contribute contribute to pathogenicity. to invasion: Compare the effects of coagulases,kinases, .Capsules hyaluronidase,and collagenase .Cell wall components .Enzymes Define and give an example of antigenic Antigenic variation variation. 一 .Penetration of the Describe how bacteria use the host cell's host cytoskeleton cytoskeleton to enter the cell.1/26/2016 4 Flagella Salmonella entering intestinal epithelial cells as a result of ruffling. Salmonella typhimurium Ruffling of host cell plasma membrane How Pathogens Penetrate Host Defenses Learning Objectives Explain how capsules and cell wall components contribute to pathogenicity. Compare the effects of coagulases, kinases, hyaluronidase, and collagenase. Define and give an example of antigenic variation. Describe how bacteria use the host cell's cytoskeleton to enter the cell. Most pathogens invade host tissues to cause disease. Factors that contribute to invasion: •Capsules •Cell wall components •Enzymes •Antigenic variation • Penetration of the host cytoskeleton