BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 F, fragment of adenosine triphophate synthase(F-ATPase) Figure 14-25 ATP synthase. As foamed finan muliple subunits GReed tters), as is the transmembrane H' Montemagno's group prepared mutants of this protein to use as ATP-fueled molecular motors for nanodevices 750-1400nm Biotinylated cysteine @@f the motor Geetabind Ni-capped post Teetor immobilization of motor hong et al., 2000) Hybrid ATPase Figure l. Schematic diagram()and CCD photomicrograph(B) of fluorescent microspheres attached to the y subunit of individual(Bachand et al., 2000) lized on nickel dot arrays that were created using electron beam lithography Lecture 13- Hybrid macromolecules 10of13BEH.462/3.962J Molecular Principles of Biomaterials Spring 2003 F1 fragment of adenosine triphophate synthase (F1-ATPase) ƒ Montemagno’s group prepared mutants of this protein to use as ATP-fueled molecular motors for nanodevices 750-1400 nm Ô Ô Ô 80 nm Hybrid ATPase Fluorescent microsphere axleÕof the motor feetÕfor immobilization of motor feetÕbind Ni-capped posts (Soong et al., 2000) (Bachand et al., 2000) Lecture 13 – Hybrid macromolecules 10 of 13