1/26/2016 Syphilis Primary stage Syphilis ·Tertiary stage Disappears affer 2 weeks -Appear years after latency if left untreated ·Secondary stage Due to cell-mediated immune reactions -Gummatous syphilis:gummas on many organs Due to an inflammatory response -Cardiovascular syphilis:weakens the aorta Latent period (after 2-4 yrs) -No symptoms -Neurosyphilis:affects the CNS:dementia -Not usually infectious except for the fetus compared to causing Congenital:neurological damage to the stillbirth in the first two stages) fetus Syphilis Viral Diseases of the Reproductive Microscopic tests Systems :nibdeare ot formed yet fo cal Learning Objective -Direct fluorescent-antibody test (DFA-TP)with monocloral antibodies Discuss the epidemiology of genital Nontreponemal serological tests(response to lipids) herpes and genital warts. 一a2eeavB8eeewseesech bode t relee Treponemal-type serological tests -Enzyme immunoassay (ETA) 一B时repeml antbody b Treatment with benzathine penicillin 1/26/2016 8 Syphilis • Primary stage – Chancre at the site of infection about 3 weeks after exposure • Painless and highly infectious • Disappears after 2 weeks • Secondary stage – Skin and mucosal rashes, especially on palms and soles • Due to an inflammatory response • L t t i d ( ft 2 Latent period (after 2-4 yrs) – No symptoms – Not usually infectious except for the fetus compared to causing stillbirth in the first two stages) Syphilis • Tertiary stage – Appear years after latency if left untreated • Due to cell-mediated immune reactions – Gummatous syphilis: gummas on many organs – Cardiovascular syphilis: weakens the aorta – Neurosyphilis: affects the CNS; dementia • Congenital: neurological damage to the fetus Syphilis • Microscopic tests – First stage; antibodies are not formed yet for serological tests – Di t fl nt Direct fluorescent-antib d t t ntibody test (DFA-TP) with m n l n l ith monoclonal antibodies • Nontreponemal serological tests (response to lipids) – Slide agglutination VDRL test (venereal disease research laboratory test/ antibodies) – Rapid plasma reagin (RPR) test (antibodies to released ag ) ents and not to the bacterium) • Treponemal-type serological tests – Enzyme immunoassay (EIA) – Fluorescent treponemal antibody absorption test (FTA-ABS) • Treatment with benzathine penicillin Viral Diseases of the Reproductive Systems Learning Objective Discuss the epidemiology of genital herpes and genital warts