Spectrum of Activity-Many G and some G* bacteria Not useful for anaerobic or intracellular bacteria (oxygen required for uptake of antibiotic Resistance -Common Synergy -The aminoglycosides synergize with b lactam antibiotics. The B-lactams inhibit cell wall synthesis and thereby increase the permeability of the membrane to aminoglycosides• Spectrum of Activity -Many G- and some G+ bacteria; Not useful for anaerobic or intracellular bacteria (oxygen required for uptake of antibiotic). • Resistance - Common • Synergy - The aminoglycosides synergize with b￾lactam antibiotics. The β -lactams inhibit cell wall synthesis and thereby increase the permeability of the membrane to aminoglycosides