The NEW ENGLAND JOURNAL f MEDICINE 886号9的的8的888e品西的芝芝受乏N 复盈豆天8尺保云8聚公家自自公8昌金含8示8888 日型8员8天88日8月网日君导888888庆份 曼红然6日日因g8石品生8贯8g8等导￥毁日 zn-6661n 00200000 us-opu E买 复是a屋a多65发兰￥盖 8 N ENGLJ MED 356:24 WWW.NEJM.ORG JUNE 14.2007T h e n e w e ng l a nd j o u r na l o f m e dic i n e 2464 n engl j med 356;24 www.nejm.org june 14 , 2007 Table 2. (Continued.) Study Drug Dose Population Study Period Age Male Sex Race† Baseline Glycated Hemoglobin Level yr percent 49653/128 Rsg/Su 4 mg Type 2 DM on concurrent Su May 1999–June 2000 58.3 51.3 100 A 9.6 Su Usual care 57.7 42.1 100 A 9.9 49653/134 Rsg/Gly/Met 8 mg Type 2 DM on Gly and Met March 1999– Aug. 2000 55.5 62.0 71 8.7 Rsg/Gly/Met 4 mg 55.6 58.0 68 8.6 Gly/Met Usual care 55.8 61.0 71 8.7 49653/135 Rsg/Glip 4 or 8 mg/ 20–40 mg Elderly patients with type 2 DM May 1999– Oct. 2002 68.7 74.1 90 7.6 Glip 20–40 mg 68.2 71.2 91 7.3 49653/136 Rsg/Su/insulin 4 or 8 mg Type 2 DM with chronic renal failure on Su, insulin, or both July 1999–June 2001 64.9 60.7 97 8.2 Su/insulin Usual care 66.3 60.8 98 8.3 49653/145 Rsg/Su 8 mg Type 2 DM Oct. 1999–Nov. 2000 61.1 57.3 97 8.5 Su Usual care 61.9 62.7 98 8.6 49653/147 Rsg/Su 8 mg Indo-Asian patients with type 2 DM July 1999–Aug. 2000 54.3 20.2 100 A 9.2 Su Usual care 54.1 25.3 100 A 9.1 49653/162 Rsg/Gly 8 mg Type 2 DM Nov. 2000–April 2002 60.0 55.1 97 7.9 Gly Maximum, 15 mg 59.9 61.8 96 8.0 49653/234 Rsg/Glim 8 mg Type 2 DM Jan. 2001–Feb. 2002 62.9 44.0 100 8.1 Rsg/Glim 4 mg 60.5 57.0 100 8.2 Glim Up-titrated 65.0 60.0 100 7.9 49653/330 Rsg 8 mg Chronic psoriasis Jan. 2003–Oct. 2004 44.3 65.0 92 NA Rsg 4 mg 44.8 66.0 91 NA Rsg 2 mg 45.0 63.0 90 NA Plc — 44.5 63.0 93 NA SB-712753/003 Rsg/Met 4 or 8 mg/1–3 g Mild type 2 DM June 2003–Dec. 2004 58.9 54.7 98 7.2 Met 1–3 g 59.0 55.5 99 7.2 The New England Journal of Medicine Downloaded from nejm.org on February 5, 2016. For personal use only. No other uses without permission. Copyright © 2007 Massachusetts Medical Society. All rights reserved