ROSIGLITAZONE AND CARDIOVASCULAR OUTCOMES 然房0品88品6gg8863芝芝388886附688云86品 公8ge的品天RRR8R9不88昌曾8品品云R8R品日昏R 份8食品厨8会88著日食牙品供牙学8份88冠发器后导发每月品 888日贷段没6云6发因员66日君甘因关安日贯谷的母份虽发日8厨 員国 掌 dy-266t ounf 3nV-6661 壁整合墨望壁望是 事a:复复1是室市 昌昌香昌 N ENGLJ MED 356;24 WWW.NEJM.ORG JUNE 14,2007 246 The New England Joumal of Medicine Rosiglitazone and Cardiovascular Outcomes n engl j med 356;24 www.nejm.org june 14, 2007 2463 49653/020 Rsg 8 mg Type 2 DM Oct. 1996–May 1998 60.9 57.6 97 8.2 Rsg 4 mg 60.4 68.2 99 8.1 Gly Titrated 60.1 70.4 99 8.2 49653/024 Rsg 4 mg once daily Type 2 DM Jan. 1997–Feb. 1998 57.5 58.6 76 8.9 Rsg 2 mg twice daily 56.8 59.1 78 8.9 Rsg 8 mg once daily 58.9 65.7 80 8.9 Rsg 4 mg twice daily 56.5 59.9 71 9.0 Plc — 57.7 68.8 79 8.9 49653/079 Rsg 4 mg Type 2 DM poorly controlled on maximum dose of Gly April 1997–March 1998 59.1 63.6 70 9.1 Rsg/Gly 4 mg/20 mg 57.7 69.4 70 9.2 Gly 20 mg 58.5 66.7 69 9.3 49653/080 Rsg 8 mg Type 2 DM Nov. 1996–May 2000 55.1 75.0 73 8.9 Gly 2.5–5.0 mg 56.1 70.1 76 9.4 49653/082 Rsg/insulin 8 mg Type 2 DM poorly controlled on insulin July 1997–Aug. 1998 57.7 54.3 71 9.0 Rsg/insulin 4 mg 57.1 56.6 72 9.1 Insulin Usual care 55.6 55.8 68 8.9 49653/085 Rsg/insulin 4 or 8 mg Type 2 DM May 2000–June 2001 61.3 54.0 99 NA Insulin Usual care 61.5 46.8 100 NA 49653/093 Rsg/Met 8 mg/2.5 g Type 2 DM poorly controlled on Met June 1997–April 1998 57.8 60.0 58 8.7 Rsg 8 mg 58.8 53.7 59 8.7 Met 2.5 g 59.5 67.0 60 8.8 49653/094 Rsg/Met 8 mg/2.5 g Type 2 DM poorly controlled on Met April 1997–March 1998 58.3 68.2 77 8.9 Rsg/Met 4 mg/2.5 g 57.5 62.1 80 8.9 Met 2.5 g 58.8 74.3 81 8.6 49653/095 Rsg/insulin 8 mg Type 2 DM poorly controlled on insulin Aug. 1997–Dec. 1998 57.4 58.9 73 9.1 Rsg/insulin 4 mg 57.8 63.9 68 8.8 Insulin Usual care 58.9 45.3 73 9.1 49653/097 Rsg 8 mg Type 2 DM Aug. 1997–Jan. 2001 55.8 72.1 74 8.9 Gly Titrated 56.0 70.8 84 8.8 49653/125 Rsg/Su 4 mg Type 2 DM May 1999–Aug. 2000 54.6 45.7 56 A 9.1 Su Usual care 57.3 42.4 59 A 8.9 49653/127 Rsg/Gly 8 mg/<20 mg Type 2 DM poorly controlled on Gly Jan. 1999–Dec. 1999 60.0 51.0 75 9.1 Gly <20 mg 59.4 66.0 75 8.9 The New England Journal of Medicine Downloaded from nejm.org on February 5, 2016. For personal use only. No other uses without permission. Copyright © 2007 Massachusetts Medical Society. All rights reserved