The NEW ENGLAND JOURNAL f MEDICINE 芝登88F的6芝受芝品号8g886888888 日总母甲云日品88日府日88员8学草8年8常8供88 是生氏片兴只居8日品烘员日份日品员88后8日日份含品98吕君 2a-0002An pe -1002um O-00z 866T yW-966t ny pue 'Apnis'sns 目皇皇道2酯：经经 246 N ENGLJ MED 356:24 WWW.NEJM.ORG JUNE 14.2007T h e n e w e ng l a nd j o u r na l o f m e dic i n e 2462 n engl j med 356;24 www.nejm.org june 14 , 2007 Table 2. Doses, Baseline Demographic Characteristics, Study Periods, and Glycated Hemoglobin Levels.* Study Drug Daily Dose Population Study Period Age Male Sex Race† Baseline Glycated Hemoglobin Level yr percent 100684 Rsg/Gly 4 or 8 mg Korean patients with type 2 DM Dec. 2003–July 2005 55.2 53.5 100 A NA Gly 5–15 mg 54.5 45.6 100 A NA 49653/143 Rsg/Gly 8 mg Type 2 DM poorly controlled on glyburide July 2000– Jan. 2003 52 45.3 44:56 B:H 9.2 Gly Usual care 53 48.3 38:62 B:H 9.4 49653/211 Rsg 4 mg Type 2 DM with CHF July 2001–Nov. 2003 64.3 84.3 99 7.7 Plc — 63.9 79.0 99 7.8 49653/284 Rsg/Met 4 or 8 mg/1 g Type 2 DM June 2001–Feb. 2003 55.5 51.1 72 8.1 Met 1–2 g 55.6 51.0 71 7.9 712753/008 Rsg/Met 8 mg/1 g Type 2 DM poorly controlled on Met June 2003–Dec. 2005 54.6 63.2 70 NA Rsg/Met 4 mg/2 g 56.0 65.2 78 NA Met 2g 56.9 53.4 69 NA AVM100264 Rsg/Met 4 or 8 mg/2 g Overweight patients with type 2 DM poorly controlled on Met July 2004–Jan. 2006 58.5 52.7 94 8.0 Met/Su 2 g/titrated 59.3 52.5 95 8.0 BRL49653C/185 Rsg/ELM/Met 4 mg/1.5 g Type 2 DM May 2000–May 2002 58.0 65.2 76 7.5 Rsg/ELM 4 mg 59.0 60.2 78 7.4 Met/ELM 1.5 g 60.0 56.4 78 7.5 ELM — 57.0 60.9 83 7.4 BRL 49653/334 Rsg 4 or 8 mg Type 2 DM or insulin resistance syndrome March 2002–Nov. 2004 67.7 44.8 99 6.3 Plc — 67.3 47.7 100 6.3 BRL 49653/347 Rsg/insulin 4 mg Type 2 DM poorly controlled on insulin Nov. 2002–April 2004 52.6 48.1 57 9.0 Rsg/insulin 2 or 4 mg 52.7 60.0 57 8.9 Insulin/Plc Usual care 53.8 46.2 57 9.1 49653/011 Rsg 8 mg Type 2 DM Sept. 1996–Sept. 1997 60.7 66.9 73 8.8 Rsg 4 mg 59.6 64.5 75 9.0 Plc — 58.8 65.8 74 9.0 49653/015 Rsg/Su 4 mg Type 2 DM Aug. 1996–March 1998 60.6 53.2 98 9.2 Rsg/Su 2 mg 61.0 62.8 86 9.2 Su 61.9 57.3 97 9.2 The New England Journal of Medicine Downloaded from nejm.org on February 5, 2016. For personal use only. No other uses without permission. Copyright © 2007 Massachusetts Medical Society. All rights reserved